Did you know to treat Gigantism surgery is the treatment of choice and can cure many cases?

Did you know that Gigantism is abnormally large growth due to an excess of growth hormone during childhood, before the bone growth plates have closed?
 Did you know that the most common cause of too much growth hormone release is a noncancerous (benign) tumor of the pituitary gland?

Did you know that Gigantism is also caused by?

• Carney complex
• McCune-Albright syndrome (MAS)
• Multiple endocrine neoplasia type 1 (MEN-1)
• Neurofibromatosis

Did you know that if excess growth hormone occurs after normal bone growth has stopped, the condition is known as Acromegaly?

Did you know that Gigantism is very rare?

Did you know that with Gigantism the child will grow in height, as well as in the muscles and organs?  

Other symptoms include:

• Delayed puberty
• Double vision or difficulty with side (peripheral) vision
• Frontal bossing and a prominent jaw
• Headache
• Increased sweating
• Irregular periods (menstruation)
• Large hands and feet with thick fingers and toes
• Release of breast milk
• Thickening of the facial features
• Weakness

Did you know to treat Gigantism surgery is the treatment of choice and can cure many cases?

Did you know that in situations in which surgery cannot completely remove the tumor, medication is the treatment of choice?


Did you know that the most effective medications are somatostatin analogs (such as octreotide or long-acting lanreotide), which reduce growth hormone release?

Dopamine agonists (bromocriptine mesylate, cabergoline) have also been used to reduce growth hormone release, but these are generally less effective. Pegvisomant, a medication that blocks the effect of growth hormone, may be used.

Did you know that radiation therapy has also been used to bring growth hormone levels to normal,  however, it can take 5 - 10 years for the full effects to be seen and almost always leads to low levels of other pituitary hormones?

Did you know that radiation has also been linked to learning disabilities, obesity, and emotional changes in children?


Did you know that most experts will use radiation only if surgery and medication fail?

Did you know that Pituitary surgery is usually successful in limiting growth hormone production.?

• Delayed puberty

Did you know that surgery and radiation can both lead to low levels of other pituitary hormones, which can cause:

• Adrenal insufficiency
• Diabetes insipidus (rarely)
• Hypogonadism
• Hypothyroidism

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Did you know that Korsakoff's syndrome is a neurological disorder caused by the lack of thiamine (vitamin B1) in the brain?

Did you know that Korsakoff's syndrome  is a neurological disorder caused by the lack of thiamine (vitamin B₁) in the brain?

Did you know that the syndrome is named after Sergei Korsakoff, the neuropsychiatrist who popularized the theory?

Did you know that there are six major symptoms of Korsakoff's syndrome?

1. anterograde amnesia^[1] and
2. retrograde amnesia, severe memory loss
3. confabulation, that is, invented memories which are then taken as true due to gaps in memory sometimes associated with blackouts
4. meager content in conversation
5. lack of insight
6. apathy - the patients lose interest in things quickly and generally appear indifferent to change.

Did you know that Korsakoff's involves neuronal loss, that is, damage to neurons; gliosis which is a result of damage to supporting cells of the central nervous system; and hemorrhage or bleeding in mammillary bodies?

Damage to the dorsomedial nucleus or anterior group of the thalamus (limbic-specific nuclei) is also associated with this disorder?

Signs

• Apathy
• Ataxia
• Coma
• Confabulation
• Paralysis of muscles controlling the eye
• Retrograde and anterograde amnesia
• Tremor
• Anosognosia - Lack of insight to or awareness of the condition

Did you know that vitamin deficiency help increase the effects Korsakoff's syndrome?

Did you know that chronic alcoholism and severe malnutrition also increase the chance that one might develope Korsakoff's syndrome?

Did you know that mercury poisoning can also lead to Korsakoff's syndrome?

Did you know that centipede (mukade) bites in Japan also cause Korsakoff's syndrome?



 There is no specific treatment because the previous thiamine deficiency produces irreversible damage to the medial thalamic nuclei and mammillary bodies. Mammillary body atrophy may be visible on high-resolution MRI.^[8]

Did you know that the most effective method of preventing Korsakoff's syndrome is to avoid B vitamin/thiamine deficiency?

Did you know that in Western nations the most common causes of such deficiency are alcoholism and weight disorders?

Did you know that in the  U.S., government mandates to adding thiamine to alcoholic beverages have been blocked for this reason and also by political groups asserting that such supplementation would encourage alcohol use.?

Did you know that Bobby Meide, a drummer for longstanding local rock band the Flamin' Ohs, passed away from Korsakoff's syndrome?

( 1950 - 2010.)



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Did you know that packages without a standard mailing or rectangular shape are eligible for Parcel Post shipping?

Did you know that Parcel Post is a service offered by the United States Postal Service (USPS) as an "affordable and reliable option for packages?

Did you Parcel Post offers a lower-cost option for shipping items that are not eligible for First Class Mail delivery?


Did you know that Parcel Post is for heavier items that do not need to be delivered within the two-to-three-business-day window Priority Mail offers, Parcel Post provides a substantial savings in the cost of postage?Did you know that any item that weighs over 13 oz is not eligible for First Class Mail shipping through the USPS and must be shipped via Priority Mail?Did you know that Parcel Post eligible items include anything mailable by the USPS?


Did you know that collectibles, toys, household goods, clothing, shoes and small pieces of exercise equipment are all examples of items eligible for shipping via Parcel Post?


Did you know that books, videos and music are also eligible for Parcel Post shipping but are more economically shipped via Media Mail?


Did you know that packages sent through the USPS via Parcel Post can measure up to 130 inches in combined length and girth and this is the largest package size allowed by the USPS.?

Did you know that a Parcel Post package that has a combined length and girth of greater than 108 inches but less than 130 inches has postage assessed at an oversized price instead of at the standard Parcel Post rate?

1. • Did you know that Parcel Post is a cost-effective shipping option when the item shipped via Parcel Post weighed up to a USPS maximum allowed weight of 70 lbs?

     Did you know that a surcharge is assessed when the package weight exceeds the 35-lb level?
   
    Did you know that packages without a standard mailing or rectangular shape are eligible for Parcel Post shipping?
   

   
   

   Did you know that mailers such as tubes and rolls as well as other irregular sized parcels that are not 26 inches or more on their longest size are assessed an additional surcharge because they are considered non-machineable?

   
   

   Did you know that Parcel Post is typically delivered within two to nine days within the lower 48 states though the size of a package or the final destination can alter this delivery time frame? 

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Did you know that John Elway went to 4 Superbowl before he finally won?

Did you know John Elway led the Broncos to Super Bowl XXI in 1987? 

Did you know that the Broncos lost the game 39–20, even though Elway had an impressive performance, throwing for 304 yards and a touchdown, with one interception, while also leading Denver in rushing with 27 yards and a touchdown on the ground?


Did you know that John Elway lead the Broncos to their second consecutive Super Bowl appearance 1988?


Did you know that the Washington Redskins won Super Bowl XXII 42–10?


Did you know that John Elway set a record for the fastest touchdown in Super Bowl history with a 1:57 seconds?


 Did you know that John Elway also became the first quarterback ever to catch a pass in the Super Bowl, recording a 23-yard reception from halfback Steve Sewell on a halfback option play? 


Did you know that John Elway lead the Bronco to there third consecutive Super Bowl in 1989 season?


 Did you know that Elway land the Broncos to Super Bowl XXIV where they losf to the San Francisco 49ers?


Did you know that the 49 ers blew out the Broncos 56-10?


Did you know it took John Elway another eight years, but he eventually led his team back to the Super Bowl in 1998?


Did you know that John Elway went to 3 straight Super bowls and lost,  before he won the Super Bowl, 8 years later?


Did you know that the John Elway won his first Super Bowl in his fourth Appearance?                                                

Did you know that the Denver Broncos defeated the Super Bowl champions Green Bay PackersSuper Bowl XXXII  31–24?


Did you know that in 1999, the Broncos repeated this feat and Elway was awarded the MVP of Super Bowl XXXIII defeating the Atlanta Falcons 31–24? 


 throwing for 336 yards and one touchdown with one interception, while also scoring a rushing touchdown in Denver's. It was his last game, other than the 1999 Pro Bowl.the Atlanta Falcons 31–24, 34–19 win over 

Did you know that John Elway has one of the best winning percentages in league history (148–82–1), and is tied for second most Pro Bowl selections for a quarterback (nine)?


Did you know that John Elway four total rushing touchdowns in his Super Bowl games are the most ever by a quarterback?


Did you know that John Elway is the only quarterback to have started in five Super Bowls?


Did you know that Jim Kelly is the only quarterback to have started in four Super Bowls and never win?

Did you know that John Elway is also the second player ever to score a rushing touchdown in four different Super Bowls (running back Thurman Thomas was the first)?

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