Did you know that Korsakoff's syndrome is a neurological disorder caused by the lack of thiamine (vitamin B1) in the brain?

Did you know that Korsakoff's syndrome  is a neurological disorder caused by the lack of thiamine (vitamin B₁) in the brain?

Did you know that the syndrome is named after Sergei Korsakoff, the neuropsychiatrist who popularized the theory?

Did you know that there are six major symptoms of Korsakoff's syndrome?

1. anterograde amnesia^[1] and
2. retrograde amnesia, severe memory loss
3. confabulation, that is, invented memories which are then taken as true due to gaps in memory sometimes associated with blackouts
4. meager content in conversation
5. lack of insight
6. apathy - the patients lose interest in things quickly and generally appear indifferent to change.

Did you know that Korsakoff's involves neuronal loss, that is, damage to neurons; gliosis which is a result of damage to supporting cells of the central nervous system; and hemorrhage or bleeding in mammillary bodies?

Damage to the dorsomedial nucleus or anterior group of the thalamus (limbic-specific nuclei) is also associated with this disorder?

Signs

• Apathy
• Ataxia
• Coma
• Confabulation
• Paralysis of muscles controlling the eye
• Retrograde and anterograde amnesia
• Tremor
• Anosognosia - Lack of insight to or awareness of the condition

Did you know that vitamin deficiency help increase the effects Korsakoff's syndrome?

Did you know that chronic alcoholism and severe malnutrition also increase the chance that one might develope Korsakoff's syndrome?

Did you know that mercury poisoning can also lead to Korsakoff's syndrome?

Did you know that centipede (mukade) bites in Japan also cause Korsakoff's syndrome?



 There is no specific treatment because the previous thiamine deficiency produces irreversible damage to the medial thalamic nuclei and mammillary bodies. Mammillary body atrophy may be visible on high-resolution MRI.^[8]

Did you know that the most effective method of preventing Korsakoff's syndrome is to avoid B vitamin/thiamine deficiency?

Did you know that in Western nations the most common causes of such deficiency are alcoholism and weight disorders?

Did you know that in the  U.S., government mandates to adding thiamine to alcoholic beverages have been blocked for this reason and also by political groups asserting that such supplementation would encourage alcohol use.?

Did you know that Bobby Meide, a drummer for longstanding local rock band the Flamin' Ohs, passed away from Korsakoff's syndrome?

( 1950 - 2010.)



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Did you know that packages without a standard mailing or rectangular shape are eligible for Parcel Post shipping?

Did you know that Parcel Post is a service offered by the United States Postal Service (USPS) as an "affordable and reliable option for packages?

Did you Parcel Post offers a lower-cost option for shipping items that are not eligible for First Class Mail delivery?


Did you know that Parcel Post is for heavier items that do not need to be delivered within the two-to-three-business-day window Priority Mail offers, Parcel Post provides a substantial savings in the cost of postage?Did you know that any item that weighs over 13 oz is not eligible for First Class Mail shipping through the USPS and must be shipped via Priority Mail?Did you know that Parcel Post eligible items include anything mailable by the USPS?


Did you know that collectibles, toys, household goods, clothing, shoes and small pieces of exercise equipment are all examples of items eligible for shipping via Parcel Post?


Did you know that books, videos and music are also eligible for Parcel Post shipping but are more economically shipped via Media Mail?


Did you know that packages sent through the USPS via Parcel Post can measure up to 130 inches in combined length and girth and this is the largest package size allowed by the USPS.?

Did you know that a Parcel Post package that has a combined length and girth of greater than 108 inches but less than 130 inches has postage assessed at an oversized price instead of at the standard Parcel Post rate?

1. • Did you know that Parcel Post is a cost-effective shipping option when the item shipped via Parcel Post weighed up to a USPS maximum allowed weight of 70 lbs?

     Did you know that a surcharge is assessed when the package weight exceeds the 35-lb level?
   
    Did you know that packages without a standard mailing or rectangular shape are eligible for Parcel Post shipping?
   

   
   

   Did you know that mailers such as tubes and rolls as well as other irregular sized parcels that are not 26 inches or more on their longest size are assessed an additional surcharge because they are considered non-machineable?

   
   

   Did you know that Parcel Post is typically delivered within two to nine days within the lower 48 states though the size of a package or the final destination can alter this delivery time frame? 

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Did you know that John Elway went to 4 Superbowl before he finally won?

Did you know John Elway led the Broncos to Super Bowl XXI in 1987? 

Did you know that the Broncos lost the game 39–20, even though Elway had an impressive performance, throwing for 304 yards and a touchdown, with one interception, while also leading Denver in rushing with 27 yards and a touchdown on the ground?


Did you know that John Elway lead the Broncos to their second consecutive Super Bowl appearance 1988?


Did you know that the Washington Redskins won Super Bowl XXII 42–10?


Did you know that John Elway set a record for the fastest touchdown in Super Bowl history with a 1:57 seconds?


 Did you know that John Elway also became the first quarterback ever to catch a pass in the Super Bowl, recording a 23-yard reception from halfback Steve Sewell on a halfback option play? 


Did you know that John Elway lead the Bronco to there third consecutive Super Bowl in 1989 season?


 Did you know that Elway land the Broncos to Super Bowl XXIV where they losf to the San Francisco 49ers?


Did you know that the 49 ers blew out the Broncos 56-10?


Did you know it took John Elway another eight years, but he eventually led his team back to the Super Bowl in 1998?


Did you know that John Elway went to 3 straight Super bowls and lost,  before he won the Super Bowl, 8 years later?


Did you know that the John Elway won his first Super Bowl in his fourth Appearance?                                                

Did you know that the Denver Broncos defeated the Super Bowl champions Green Bay PackersSuper Bowl XXXII  31–24?


Did you know that in 1999, the Broncos repeated this feat and Elway was awarded the MVP of Super Bowl XXXIII defeating the Atlanta Falcons 31–24? 


 throwing for 336 yards and one touchdown with one interception, while also scoring a rushing touchdown in Denver's. It was his last game, other than the 1999 Pro Bowl.the Atlanta Falcons 31–24, 34–19 win over 

Did you know that John Elway has one of the best winning percentages in league history (148–82–1), and is tied for second most Pro Bowl selections for a quarterback (nine)?


Did you know that John Elway four total rushing touchdowns in his Super Bowl games are the most ever by a quarterback?


Did you know that John Elway is the only quarterback to have started in five Super Bowls?


Did you know that Jim Kelly is the only quarterback to have started in four Super Bowls and never win?

Did you know that John Elway is also the second player ever to score a rushing touchdown in four different Super Bowls (running back Thurman Thomas was the first)?

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Did you know that when using Cloud Computing the amount of computing horsepower we need will be greatly reduced?

Did you know that cloud computing in the most layman of terms,  simply refers to resources and applications that are available on the Internet

from just about any Internet connected device?

Did you know that webmail is an aspect of cloud computing?

Did you know that if you use Web mail services like Gmail, Yahoo, Hotmail and so forth, your e-mail is considered “in the cloud” because you can access it from any device with Internet access?

Did you know that in the broader sense, cloud computing is used to describe any and all applications and services hosted and run on servers connected to the Internet – servers and applications that end users (you and I) do not have to maintain or support?

Did you know that the fee-based service that is offered by Carbonite, which lets you you to back up your data to a remote server is a great example of the Cloud?

Did you know that when you use the the Cloud Computing concept that it is often more economical for users or companies in many cases?

 Did you know that when using Cloud Computing the amount of computing horsepower we need will be greatly reduced?

 Did you know that the Cloud Computing concept is especially significant as more and more of our computing needs are being served by smaller and smaller devices such smartphones and tablets?

Did you know that with Cloud Computing it offers you the opportunity to not run intensive applications like Photoshop or CAD programs on your personal computer, you upload your data to a computer in the cloud and it does all the heavy lifting and returns to you a finished product?

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Did you know the American Idol contestants Carrie Underwood & Kelly Clarkson never appeared in the bottom two or three?

Kelly Clarkson

Carrie Underwood

Did you know the American Idol contestants Carrie Underwood & Kelly Clarkson never appeared in the bottom two or three?









 
Did you know that Lee DeWyze and Crystal Bowersox join Kelly Clarkson, Clay Aiken, Carrie Underwood, Taylor Hicks, Jordin Sparks, David Cook, and David Archuleta are members of the final two club who had never been in the bottom two or three?

Lee DeWyze 

Crystal Bowersox

Taylor Hicks

Jordan Sparks

David Cook

David Archuleta

Clay Aiken

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